Antigenic Site Detection and Designing of a Potential Vaccine candidate against Listeria monocytogenes a Cause of Listeriosis using Reverse Vaccinology

Abstract “Listeriosis” is the recent pandemic caused by a bacterium named Listeria monocytogenes an intracellular pathogen causes very high mortality rates in the United States. In the Current study, an effort was taken to design a Potent Subunit vaccine against L. monocytogenes applying the reverse vaccinology approach. The method includes screening of complete proteome based […]

Effect of Low Power mm wave Irradiation on sedimentation, coagulation and light absorbance of purified Bovine Serum Albumin

Abstract Globular protein Bovine Serum Albumin is water soluble and is sensitive to Low Power mm Wave (Micro wave) irradiation leading to Coagulation at the isoelectric Point.The objective of the work was to study the effect of these radiations on the coagulation and light absorbance of purified bovine serum albumin protein. When a heat stress […]

ROHYPNOL®: A Review on Abuse as Date Rape Drug

Abstract Date rape drug refers to a drug that can be used to assist in the execution of a sexual assault, such as date rape. Sexual assault is any type of sexual activity that a person does not agree to. Drugs used to facilitate rape may have sedative, hypnotic, dissociative and/or amnesiac effects, and can […]

An Insilico approach to design the mutated 3D structure of BCHE using AB initio method and testing the efficacy of the selected ligands in inhibiting the S226G mutation

Abstract Butyryl cholinesterase (BCHE) is a protein belonging to ester lipase super family. It hydrolyzes choline esters in addition to its role in nerve impulse transmission. BCHE has three active sites located at 226, 353 and 456 which are responsible for acyl ester intermediate, and charge relay system. Among the three sites, 226 (serine) have […]

Analysis of Variations in Conserved Motifs of Cag A protein in Different Helicobacter Pylori Strains

Abstract Infection with strains of Helicobacter pylori that carry the cytotoxin-associated antigen a (cagA) gene is associated with gastric carcinoma. Recent studies have shed light on the mechanism through which the cagA gene product, CagA, elicits pathophysiological actions. Helicobacter pylori infection has an association with histological gastritis, gastric atrophy, gastric cancer, and mucosa-associated lymphoid tissue […]