Molecular Characterisation of HBB and associated Polymorphism rs33915217 Involved in Beta Thalassemia

Abstract Mutations in the HBB (Haemoglobin subunit beta) can cause several diseases. β-Thalassemia is one such disease which has no cure. β-Thalassemia can cause abnormal Beta chains in the haemoglobin molecule or in some cases be absent altogether.  Numerous polymorphisms have been identified which can cause β-Thalassemia but one of the more prominent ones is […]

Prediction of Protein Secondary Structure Using LIBSVM and SSVM with different Kernel Function

Abstract Bioinformatics and computational biology is the emerging field of research in current era. Proteomics is solitary of the prime areas of research in bioinformatics. The general function of proteins is mostly dictated by structure. Prediction of secondary structure plays a key role in its further prediction of tertiary structure. Several techniques have been proposed […]

Isolation and Identification of Pseudomonas aeruginosa from different sources (soil, wound, urine) and Checking its MIC with various Antibiotics

Abstract Pseudomonas is a group of bacteria found in soil, water, skin flora and most man- made environments throughout the world. Pseudomonas infections may cause disease, generalized inflammation and sepsis. The targeted organism for this organism are the lungs, the urinary tract, and kidneys, the result can be fatal. It can also be found on medical […]

Targeting Human Bocavirus VP-2 Protein by Combining Pharmacophore, Molecular Docking and ADME-Tox Approaches to Identify Best-Optimized Novel Drug Candidate

Abstract Human bocavirus (HBoV) belongs to a parvoviridae family. It has a single-stranded DNA etiologic agent and is known to cause lower respiratory tract infections in small and young children all over the world. Currently, there is no treatment or vaccination. The aim of the study was to describe the Human bocavirus VP 2 protein […]

Transformation of Antibiotic Resistant Gene from Staphylococcus Species to E.coli Dh5 Alpha Sensitive Strain

Abstract Natural genetic transformation is the active uptake of free DNA by bacterial cells and the heritable incorporation of its genetic information. In the current work, Transformational insertion of an Antibiotic resistant gene (Ampicillin) from the native bacteria transformed into the sensitive strain of E. coli DH5 alpha. The bacteria were isolated from stagnant water […]

A Study on Association of Single Nucleotide Polymorphisms on CACNA1A Gene with Migraine in South Indian Population

Abstract Mechanism based migraine therapy gained steam in early 1990s and has led to an extensive research for improved understanding of genetics of classical and common migraine, as each has its own hereditary characteristics. This has steered the researchers to associate single nucleotide polymorphisms (SNPs) to migraine. rs16023 of CACNA1A gene is one among the […]

In silico Annotation and Antigenic Peptide Identification of Staphylococcus Enterotoxins

Abstract Staphylococcus has long back gained its importance in causing several diseases especially skin diseases. It is known to have the capability of enterotoxin production which constitutes for its pathogenicity. Being resistant to several antibiotics, causes hurdles in the treatment. The current work aimed to annotate in detail the selected Enterotoxins SEA, SEB, SEC, SED […]