Transformation of Antibiotic Resistant Gene from Staphylococcus Species to E.coli Dh5 Alpha Sensitive Strain

Abstract Natural genetic transformation is the active uptake of free DNA by bacterial cells and the heritable incorporation of its genetic information. In the current work, Transformational insertion of an Antibiotic resistant gene (Ampicillin) from the native bacteria transformed into the sensitive strain of E. coli DH5 alpha. The bacteria were isolated from stagnant water […]

A Study on Association of Single Nucleotide Polymorphisms on CACNA1A Gene with Migraine in South Indian Population

Abstract Mechanism based migraine therapy gained steam in early 1990s and has led to an extensive research for improved understanding of genetics of classical and common migraine, as each has its own hereditary characteristics. This has steered the researchers to associate single nucleotide polymorphisms (SNPs) to migraine. rs16023 of CACNA1A gene is one among the […]

In silico Annotation and Antigenic Peptide Identification of Staphylococcus Enterotoxins

Abstract Staphylococcus has long back gained its importance in causing several diseases especially skin diseases. It is known to have the capability of enterotoxin production which constitutes for its pathogenicity. Being resistant to several antibiotics, causes hurdles in the treatment. The current work aimed to annotate in detail the selected Enterotoxins SEA, SEB, SEC, SED […]

In silico Vaccine designing for Lyme disease

Abstract The vaccine designing project for Lyme disease involves various Bio-informatics tools and techniques for Insilico designing of a vaccine. Lyme disease is caused by the bacterium Borrelia Burgdorferi also called as Lyme Borreliosis or Lyme Arthritis. The bacterium uses ‘Ticks’ as vectors and infects Humans through tick bites. The symptoms can start from simple […]

MODERN DECELLULARIZATION SCAFFOLD FRAMING FROM PORCINE HEART VALVE

Abstract Tissue engineering heart valve is a novel experimental concept to develop ideal heart valve substitutes. Conventional mechanical valve used for replacement require the anti-coagulation therapy which decreases quality of life. Now a days bioprosthetic heart valve replacement are either of animal origin such as porcine pulmonary or aortic valves and bovine pericardial valves or […]