Abstract Brain Derived Neurotropic Factor (BDNF) is a protein well recognized for its involvement in the growth and development of Neuronal system and synaptic plasticity. It plays a key role in Energy metabolism and Food intake. Studies were carried on the involvement of BDNF in the treatment of Diabetes and Obesity. The present study is […]
Abstract The present study involves production of cellulolytic enzymes by a newly isolated strain of Aspergillus niger isolated from decaying sugarcane bagasse. Solid-state-fermentation was employed using sweet sorghum bagasse as the substrate for the production of enzyme. One factor at a time approach was used to optimize the process variables like moisture content, pH, temperature, […]
Abstract Microsatellites are small nucleotide repeats which are formed by tandem repetition of motifs of size 1-6 bp. These repeats play an important role in Genome evolution, Associated with various diseases, Used as molecular markers in DNA Fingerprinting, Population Genetics, Paternity Studies, Forensics, etc. Various bioinformatics tools are being used for extraction of STRs during […]
Abstract In this paper a novel concept of designing and building intelligent expert system for the detection and diagnosis of Diabetes Mellitus is introduced. The expert system classification is based on critical diabetic parameters like Brain-Derived Neurotrophic Factor (BDNF) levels, and Fasting Blood Glucose (FBG). The proposed rule-based expert system constructs large-scale knowledge-base based on […]
Abstract Alzheimer’s disease (AD) or Senile Dementia of the Alzheimer Type (SDAT) is a progressive neurologic brain disease leading to irreversible loss of neurons and loss of intellectual abilities, including memory and reasoning, which impedes social or occupational functioning. During the course of the disease, plaques and tangles develop within the brain. This causes neuronal […]
Abstract TB is major public health problem in Asia especially in India. In India, annually more than 3,30,000 patients die due to tuberculosis (TB). Recently due to multiple drug therapy, cases of adverse drug reactions are increasing. Nowadays TB and Human immunodeficiency virus (HIV) are most common, and having high prevalence rate. Treatments to both […]
Abstract Phytases are the enzymes which hydrolyze phytic acid, a major storage form of phosphorus in cereals and legumes, to less phosphorylated myo-inositol derivatives releasing inorganic phosphate. The supplementation of animal feed with phytases reduces the cost of diets by removing or reducing the need for supplemental inorganic phosphate and increases the bioavailability of phosphorous […]
Abstract Rice (Oryza sativa L.) is a primary source of food for billions of people throughout the world, yet it contains insufficient levels of the key micronutrients iron, zinc and vitamin A to meet the daily dietary requirements. Biofortification of staple food crops has thus been considered a sustainable strategy to overcome the problem of […]
Abstract RAS subfamily belongs to a class of proteins called small GTPase, which are a group of hydrolase enzymes that can bind (‘on state’) and hydrolyze (‘off state’) guanosine triphosphate (GTP). Hence, RAS proteins act as binary molecular switches and play a consequential role in intracellular signal transduction which regulates processes such as actin cytoskeletal […]
Abstract Glycation is the non-enzymatic addition or insertion of sugar molecules into DNA, proteins and lipids that occur in biological molecules. The glycation of DNA gives rise to characteristic nucleotide adducts, some of which have been found to increase in oxidative stress. The glycation causes damage to DNA which is associated with mutagenesis, carcinogenesis and […]