Abstract Diabetes, growing global health burden is a Multifactorial, heterogeneous group of disorders characterized by deficiency or failure in maintaining normal glucose homeostasis. The prevalence of Diabetes is rising across the globe at an alarming rate with India and china facing the greatest challenges with worsening trend affecting younger age groups. Diabetes and its complications […]
Abstract Some of the fruits and vegetables that are used in our daily life have proved to be effective in treating the microbial and fungal infections. The current work was done to identify the anti microbial capacity of selected fruit extracts so as to design a more simple and economic means to treat these infections. […]
Abstract The present investigation is carried out to determine the anti-microbial activity of Cassia tora leaves and stem crude extracts at various concentrations. Agar well diffusion method is used to determine both anti-bacterial and anti-fungal activities. The phytochemical analysis was carried out to screen the presence of alkaloids, tannins and cardiac glycosides so as to […]
Abstract Photosynthetic prokaryotes and eukaryotes, namely phytoplankton, chromophytes and cyanobacteria use the Calvin – Benson – Bassham (CBB) pathway to metabolize CO2 [1]. The key enzyme of the CBB pathway is ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCo). RuBisCo-based CO2 fixation occurs in all cyanobacteria through C3 intermediates. The RuBisCo plays a pivotal role in linking the inorganic (CO2) […]
Abstract Prox1 gene encodes for the homeo domain protein. It is the mammalian homologue of the gene prospero in Drosophila. The gene has a vital role in the development of brain structure and is crucial for learning and memory. In view of its importance the present work aims to use the Insilico tools and softwares […]
Abstract This is a prospective study conducted in the SRM Medical College Hospital and Research Centre, Tamil Nadu from April 2010 to July 2010 to find out the prevalence of NFGNB in the clinical specimens and to isolate and identify the prevalent NFGNB from different clinical samples received in SRM medical college laboratory. Confirmation of […]
Abstract Osteoarthritis (OA) is a degenerative joint disease which occurs mainly due to aging and mechanical stress. So far only temporary methods like giving pain alleviating drugs are employed for the treatment of OA but a permanent solution to cure the disease has not yet been established. The need of the hour is to find […]
Abstract The increased incident and rapid spread of drug resistance in Plasmodium falciparum has become a major public health obstacle in India. Multi-Drug Resistance1 (MDR1) Protein has been one of the major protein to resist various types of antimalarial drugs. There is a need to develop new drugs against malaria combating the drug resistance ability […]
Abstract “Listeriosis” is the recent pandemic caused by a bacterium named Listeria monocytogenes an intracellular pathogen causes very high mortality rates in the United States. In the Current study, an effort was taken to design a Potent Subunit vaccine against L. monocytogenes applying the reverse vaccinology approach. The method includes screening of complete proteome based […]
Abstract Single-nucleotide polymorphisms (SNPs) play a major role in the understanding of the genetic basis of many complex human diseases. The current study reports, of the total of 682 SNPs in the CHK2 gene, 10 non-synonymous SNPs (nsSNPs) were identified as functionally significant. SIFT, PolyPhen and I -Mutant programs were used to analyze the nsSNPs. […]