Pharmacogenomics in Diabetes Mellitus: Pathway to Personalized Medicine

Abstract Diabetes, growing global health burden is a Multifactorial, heterogeneous group of disorders characterized by deficiency or failure in maintaining normal glucose homeostasis. The prevalence of Diabetes is rising across the globe at an alarming rate with India and china facing the greatest challenges with worsening trend affecting younger age groups. Diabetes and its complications […]

Anti-microbial activity of Cassia tora leaves and stems crude extract

Abstract The present investigation is carried out to determine the anti-microbial activity of Cassia tora leaves and stem crude extracts at various concentrations. Agar well diffusion method is used to determine both anti-bacterial and anti-fungal activities. The phytochemical analysis was carried out to screen the presence of alkaloids, tannins and cardiac glycosides so as to […]

In silico Characterization and Homology Modeling of Cyanobacterial RuBisCo (LS) with Computational Tools and Bioinformatic Servers

Abstract Photosynthetic prokaryotes and eukaryotes, namely phytoplankton, chromophytes and cyanobacteria use the Calvin – Benson – Bassham (CBB) pathway to metabolize CO2 [1]. The key enzyme of the CBB pathway is ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCo). RuBisCo-based CO2 fixation occurs in all cyanobacteria through C3 intermediates. The RuBisCo plays a pivotal role in linking the inorganic (CO2) […]

Antigenic Site Detection and Designing of a Potential Vaccine candidate against Listeria monocytogenes a Cause of Listeriosis using Reverse Vaccinology

Abstract “Listeriosis” is the recent pandemic caused by a bacterium named Listeria monocytogenes an intracellular pathogen causes very high mortality rates in the United States. In the Current study, an effort was taken to design a Potent Subunit vaccine against L. monocytogenes applying the reverse vaccinology approach. The method includes screening of complete proteome based […]