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Diabetes is prevalent world-wide and is stated to be a silent killer. Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia resulting from defects in insulin secretion, insulin action or both. There are hundreds of medicinal plants that have a long history of curative properties against various diseases and ailments. A variety of plant preparations have been mentioned in Ayurveda and other indigenous systems of medicine, which are claimed to be useful in the treatment of diabetes mellitus. In our study, the herb Coccinia indica was targeted to treat diabetes mellitus. In present work, Thermal refluence distillation concentrator is used as the reactor for herbal plant extraction and the herb residue should be drained out after the solvent recovery. The content of the capsule powder is dissolved in methanol and TLC studies of the methanol extract has been carried out and compared with the reference standard synthetic medicines used for diabetes e.g. glibenclamide, tolbutamide, acetohexamide, g1ipizide, tolazamide, chlorpropamide, g1ucophage, repaglinide and actos using different mobile phases. The above compounds were found absent in the capsule contents. The capsule content is chromatographed with the Coccinia indica plant extract (provided with the sample) which were found identical with each other. Thus our studies have shown that the product Qcciniaherb® is 100% natural extract from Coccinia indica and it has an optimal effect in combination with vitamin D3. The herbal medicine is used for Diabetes mellitus and its late effect to regulate and reduce blood sugar level naturally, improves blood lipid levels and reduces insulin resistance, and helps in glycemic control.
Actos, Acetohexarnide, Chlorpropamide, Coccinia indica, Diabetes mellitus, Glibenclamide, G1ucophage, G1ipizide, Qcciniaherb®, Repaglinide, Thermal refluence distillation concentrator, TLC, Tolbutamide and Tolazamide.
Diabetes mellitus is a group of metabolic diseases in which a person has high blood sugar, either because the pancreas does not produce enough insulin (Shoback, 2011). Diabetes doubles the risk of cardiovascular disease and it also damages the capillaries. There are two major types of diabetes. Type 1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the islets of Langerhans in the pancreas, leading to insulin deficiency. Type 2 diabetes mellitus is characterized by insulin resistance, which may be combined with relatively reduced insulin secretion (Shoback, 2011). Indian system of traditional knowledge (Ayurveda) is well known for its effective herbal treatments. There are about 7000 plant species found in India. Coccinia indica a herb that belongs to Cucurbitaceae family and that grows abundantly in India, has been widely used in traditional treatment of diabetes (Chopra et al, 1958). The plant has also been used extensively in Ayurvedic and Unani practice in the Indian subcontinent (Wealth of India, 1992). Coccinia indica is a good wound healer and reduces any kind of inflammation occurring in body. Herbal substances are new and scientifically well- to lower blood sugar and reduce the late complications of diabetes mellitus. Pectin isolated from many other plants has also been reported to have hypoglycemic actions. The pectin administration resulted in a significant reduction in blood glucose and an increase in the liver glycogen. Research suggests that vitamin D could play a role in the prevention and treatment of a number of disease conditions, including type1 and type 2 diabetes, hypertension, glucose intolerance, and multiple sclerosis. People with type 2 diabetes who suffer from vitamin D3 deficiency can be treated by the administration of vitamin D3 which improves insulin secretion and promotes glucose intolerance and impaired insulin secretion. Scientific studies show a clear link between low vitamin D status and increased number of new cases of type 2 diabetes. Recent scientific studies have shown that regular intake of vitamin D3 contributes to an improvement in insulin secretion. Qcciniaherb® is 100% natural extract from Coccinia indica for vitamin D3. The herbal product has been specially adapted for diabetes. It support pancreas to work healthy and effectively. It is purely a natural product with out chemical additives, thus it reduces and regulates blood sugar naturally. It also reduces the blood lipids such as cholesterol and triglycerides. Coccinia indica seems like insulin work. The plant corrects the activity of glucose 6 phospahatase, lactate dehydrogenase in the glycolytic metabolism with lipoprotein lipase activity in the controlled lipolytic pathway. It helps in glycemic control. With regular use of Qcciniaherb® there is less blood glucose fluctuations. This means that the blood sugar level drops and remains rather constant. The best evidence for the effectiveness of a plant with diabetes, however identify on Coccinia indica. It also reduces the late damage or complication form diabetes mellitus. The main ingredients of the herbal product are Coccinia indica extract, 81.7% hydroxypropyl methylcellulose, separating agent: magnesium salts from edible fatty acids (vegetable), Silicon dioxide, cholecalciferol 0.16% from of lactose, gluten and genetically modified organism.
Coccinia indica may be useful for the treatment of patients with diabetes melltitus without having any toxic effect. The combination with vitamin D3 have a possitive effect of insulin secreation, improves glycemic control in diabetes patients themselves and insulin resistance. The main advantage of Qcciniaherb® from other product is that, it is purely natural basis herbal product. It acts quiclky with regular use and no heavy metals are used in the preparation of Qccinia herb®. The studies and tests have revealed that the blood suger quickly after ingestion was approximately lowered to 20mg/dL.
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