Extraction of Medicinal Compounds and Analysing their Anticancer Activity of Ammomum subulatum, Curcuma longa, Cinnamomum verum and Glycyrrhiza glabra & In-Silico Analysis Of km23-1, A Cancer Receptor

Author Name: *Tanu Kinra, K. Surendra Babu, Jyothsna Gundlapally
Author Email: tanuk.shona@gmail.com

Abstract

Nature is a unique source of different high value chemical compounds, many possessing interesting biological specificities and unique medicinal properties. In the worldwide deadly conditions of variety of cancer occurring today, there is an urgent need for an intensive search for natural chemical compounds for prevention. Spices used in food preparing contains a rich wide variety of such essential compounds which on correct use can even cure these deadly diseases possessing worldwide threat. Such four spices Ammomum subulatm, Cinnamomum verum, Glyccyrhhiza glabra and Curcuma longa regularly used in food preparing and home remedies are tested upon colon cancer cell lines, COLO 320DM for their effect on cancer cells the results were amazing. Black cardamom (A.subulatum) extracts showed interesting cancer cell growth prohibition property and other extracts showed cancer cells destroying properties. When the SDS of these extracts was done and the compounds obtained were analysed in-silico for drug designing by docking, it showed that many drugs could be designed some specific to target and some non-specific for colon cancer prevention and cure. The intake of these compounds on regular bases will definitely prove as “PREVENTION IS BETTER THAN CURE”.

Introduction

Nature is a unique source of structure of high stereo chemical diversity, many of them possessing interesting biological activities & medicinal properties. In the context of worldwide deadly conditions such as variety of cancer (colon, breast, skin, ovary, retinal, blood, etc.) & AIDS & Hepatitis, an intensive search for lead chemical compounds for the development of novel pharmacological therapies is extremely important. These compounds being natural on one hand possess no harm to biological system in future on the other. The fact that since past long most of the spices used in food preparing are of real importance in INDIAN AYURVEDA has led to the discovery of many novel drugs obtained from natural compounds.
Elaichi (BLACK CARDAMOM):
Scientific name: Amomum subulatum: It is a seed pod, since antiquity known for its mouth refreshing smell, its culinary uses and its medicinal properties. In home remedies black cardamom is used for stomach disorders, malaria and throat infection. Many of its compounds have anti-oxidant, disease curing and health promoting properties. It also contains many essential oils like pinene, sabinene, myrcene, phellandrene etc.
Cinnamon: Scientific name: Cinnamomum verum. It has a very nice peculiar fragrance and is being used since biblical times for its medicinal and culinary properties. The pungent smell and scent is due to the presence of cinnamic aldehyde and cinnmaldehyde in the oil. It is best known for its anti-oxidant, anti-diabetic, anti-septic, local anesthetic, anti-inflammatory, rubefacient(warming and soothing), carminative anti-flatulent properties. Turmeric: Scientific name: Curcuma longa. The roots and leaves have long been used in traditional Indian and Chinese medicines as anti-inflammatory, pain-killer, anti-oxidant and anti-cancerous. It is best known for its inhibition properties against multiplying tumor cells. The oils present in it include termerone, curlone, curumene, cineole and p-cymene, all having applications in cosmetic industries. Mulethi: Scientific name: Glycyrhhiza glabrae. It can be used as a good remedy in treatments of viral hepatitis,
throat infection, cough, etc. having strong anti-viral effect. Glycyrrhizin from Glycyrrhiza root has been shown to modulate airway constriction, lung inflammation. Colon Cancer:
Colon cancer includes cancerous outgrowths in the colon, rectum and appendix. With 655,000 deaths worldwide per year, it is the third most common form of cancer and second leading form of cancer related deaths in the western world. Many colorectal cancers are thought to arise from adenomatous polyps in the colon. These mushroom like outgrowths are usually benign, but some may develop into cancer overtime.
The current study focused on the protein Mn23-1, the protein that is especially responsible for colon cancer. This protein is present in all colon cancer cells. So, the study focused to design a drug against this protein to stop colon cancer cells proliferation and growth

Conclusion

From the above works it can be concluded that black cardamom can be best used as the treatment remedy for cancer control and even prevention. Cardamom extract was efficient in preventing the uncontrolled cell proliferation without killing the cells. The extract has posed a barrier on the cell division which was one of the very good effects seen. On the other hand, turmeric, mulethi and liquorice killed the cancer cells at certain interval of time, proving that they can be used as targeted drugs for cancer treatment rather as a basic drug for cancer prevention because an overdose can also be fatal for normal body cells and the normal surrounding cells.
The study suggests that the regular use of cardamom in may prove as a good prevention for cancer. Similarly the spices such as mulethi and liquorice can also be employed for the same. The compounds obtained from all the four spices after docking, suggests that drugs can be made by their combinations or even solely against cancer and more specifically for colon cancer. The drug will really prove best as a cure in cancer treatment.

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