Biochemical Behavior of Some Newly Synthesized Poly Nuclear Complexes of Tungsten

Author Name: *V.K. Srivastava
Author Email: vksrivastava633@gmail.com

Abstract

Tungsten is of interest due to the role in Biological stystem. DithioCarbamates, the derivative of Dithiocarbamates acids are important on account of their wide applications; it contains Sulphur donor atoms which have tendency to from complexes with Tungsten Metal. Polynuclear complexes of Tungsten have been Synthesized and characterized by different methods. Physical and Analytical measurements like conductivity measurement, TLC Technique were used to check the purity of Synthesized compounds. Physico-chemical methods like IR, Electronic, 1H1 NMR spectral studies have been used to find out the geometry of Synthesized complexes. Result shows that dithiocarbamates ion allows the formation of strong multinuclear bridging complexes with Tungsten metal with reduced tendency to dative bond formation from metal to sulphur atom.
Biocidal studies of compounds against certain microbial species have been carried out by serial dilution method using BOD incubator to evaluate the MIC (Minimum inhibitory concentration) value. On the basis of MIC value it is interpreted that Tungsten complexes are most active as compared to ligand fragments. Plasmodium species were used for antimalarial screening. Antimalarial activity is expressed in IC50 value. In addition The DNA binding ability of the active compounds was examined by using biophysical spectroscopic studies. These studies indicate that the compounds can intercalate and stabilize DNA. This work has great importance in the field of Bioinorganic relevance because there is a major relationship between the Physiological role of the enzyme formate dehydrogenase.

KeyWords

Antimalarial, Biocidal, DNA Binding affinity, Ic50 value, Spectra, Synthesis.

Introduction

The dithiocarbamates [1] were discovered as a class of chemical compounds early in the history of organosulphur chemistry. The parent compound, dithiocarbamic acid can be obtained as colorless, needles from its ammonium or sodium salts by treatment with cold acid. The dithiocarbamate ligand is one of those polyatomic ligands which can stablize higher oxidation states of Transition metals in their complexes. The strong metal binding properties of dithiocarbamates are directly related with the presence of two donor sulphur atoms which primarily determine the nature of the metal that can be bound and the strength of complexes formed. Multinuclear compounds of Tungsten have been synthesized and characterized by different methods. The compounds of Tungsten have biological properties [2] which include antimicrobial, antimalarial and anticancer activities. Moreover drugs that are capable of targeting DNA are of substantial interest because their potential use in cancer chemotherapy. Interaction between small molecules and DNA has emerged as an area of research being widely investigated. These interactions play a central role to define the local structure of Nucleic acids as well as to design novel drug. chemotherapeutic agents etc. Metal complexes can bind to DNA through a series of interactions like coordination by the DNA bases, intercalation and Non-covalent interaction including hydrogen bonding between the coordinated ligands and phosphate oxygen atoms of the sugar phosphate group. Binding may induce cleavage of Nucleic acids which may be considered as an enzymatic reaction comprising various biological processes as well as biotechnological manipulation of genetic material. The synthesized tungsten complexes were studied for Biocidal effect, antimalarial activity and as well as the effect of metal ion on the DNA binding mode. This work has great importance in the field of Bioinorganic relevance.

Conclusion

In this paper we investigate, synthesis, characterization of new tungsten complexes with dithiocarbamate ligands, Biocidal, antimalarial activity and the DNA binding ability of the complex was examined by using biophysical spectroscopic studies. The invitro antimicrobial studies revealed that the tungsten complexes are potentially active against Bacterial and fungal species and exhibit greater Biocidal effect as compared to the ligand fragments. The compounds were found to exhibit significant antimalarial activity the results suggest that antimalarial activities are strongly affected by percentage of sulphur content. The DNA binding ability of complex indicates that the complex can intercalate and stablize DNA. Our finding may give a new application and open a new way in the design of more effective and useful tungsten complexes for synthetic as well as medicinal chemists.

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