Intergenic Interactions and Hyperplastic Diseases of Endo- and Myometrium

Author Name(s): Irina V. Ponomarenko, Vladimir F. Kulikovskiy, Evgeny N. Krikun, Alexander A. Dolzhikov, Mikhail I. Churnosov
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This paper presents the results of bioinformatic analysis of three polymorphic loci in 170 women who suffer from a combination of uterine fibroids with endometrium hyperplastic processes and in 981 women of the control group without proliferative diseases of pelvic organs. It was found that the combinations of molecular genetic markers С rs673220, А rs4986938 и G rs887912 (ОR=1.70) are risk factors for the development of a combination of endometrial hyperplasia and uterine myoma among women of the Central region of Russia


Among the gynecological incidence, the hyperplastic processes of the endometrium occupy a leading place and amount to 10-50% [Boyraz G. et al., 2016]. Endometrial hyperplasia is a pathological process affecting the epithelial and stromal components of the endometrium and is manifested by an increase in the total number of glands [Clement N.S. et al., 2016]. Atypical endometrial hyperplasia is a precancerous condition, which can cause the development of endometrial cancer in 15-45% of cases [Kadirogullari P. et al., 2015]. The risk of development of endometrial cancer in women increases significantly with age and ranges from 5 to 10% [Kim M.-J. et al., 2016]. Uterine myoma is a benign monoclonal tumor composed of the smooth muscle cells of the myometrium. The prevalence of uterine fibroids ranges from 5% to 65%, depending on age, ethnicity, geographic region and diagnostic method [Gurusamy K.S. et al., 2016]. According to the literature, uterine fibroids are most often observed in women of reproductive age (about 40%) [Khan A.T. et al., 2014] and reaches a peak at 50 years [Zimmermann A. et al., 2012]. According to various data, surgical interventions are performed in 25-50% of women diagnosed with uterine myoma [Gurusamy K.S. et al., 2016].
According to literature data, the combination of endometrial hyperplasia with uterine myoma occurs in 30-35% of patients, due to the common etiology, risk factors and key pathogenetic links [Tan N. et al., 2014]. The well-known risk factors for the development of proliferative diseases of the uterus include age, early menarche, late menopause, absence of pregnancy in history, obesity, diabetes, family history, lifestyle, etc. [Segars J.H. et al., 2014; Chandra V. et al., 2016]. The leading premium in the etiopathogenesis of hyperplastic processes of the endometrium and uterine myoma is set on excessive estrogen stimulation, hormone-independent proliferation, inflammation, reduced apoptosis, pathological neoangiogenesis, and cytogenetic disorders [Segars J.H. et al., 2014; Chandra V. et al., 2016].


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