Epidemiological studies from MP pneumonia and you will RWE away from 2003 to help you 2014

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Epidemiological studies from MP pneumonia and you will RWE away from 2003 to help you 2014

Statistical study

All calculations were performed with SPSS V.14.0 (SPSS Inc.)parisons between groups were performed using the Student’s t-test, ? 2 test and Fisher’s exact test, and the data were expressed as mean±SD for continuous variables. A p value of <0.05 was considered statistically significant.

Overall performance

The brand new victims in the modern studies have been 793 clients having MP pneumonia and you will 384 customers with RWE in the data several months. To own epidemiological analysis, an entire 793 clients were utilized, since found in in the past penned article.14 For medical evaluation between your groups, a total of 501 MP pneumonia patients that were accepted through the new present epidemics (241 instances inside the 2007–2006, and you will 260 circumstances last year), and you can 384 patients which have RWE have been analysed (figure step 1). Within the data several months, the quantity of acknowledge customers at the all of our company try an excellent overall 25 911 (but nursery people). There had been whenever 2100 acknowledge patients annually with variations during the every year.

The majority of MP pneumonia customers had go after-up period at bookofmatches zaloguj siÄ™ the very least three years out of last crisis 12 months from 2011, nevertheless the pursue-upwards victims satisfied with all of our selection conditions have been 180 certainly 501 cases throughout the MP pneumonia class and you may 206 one of 384 instances throughout the RWE class.

When you look at the MP pneumonia people, there are obvious episodes out-of circumstances in the 2003, 2006–2007 and you may 2011, with times occurring regarding interepidemic periods. There had been relatively regular amounts of RWE cases every year during the analysis several months. There were zero associated increased cases into the MP pneumonia epidemic decades except inside 2007 (shape 2). No MP pneumonia diligent who was simply readmitted on account of MP reinfection across the epidemics is actually seen during investigation several months. The new mean ages and ages delivery was in fact similar, therefore the peak age range was indeed dos–5 years old both in groups (shape step three). In the seasonality away from each other organizations, MP pneumonia is actually prevalent within the coming down purchase from trip, june, winter and you will springtime, while customers having RWE was in fact very commonplace from inside the autumn, with springtime, winter season and you can june (data perhaps not shown).

Group and you will medical functions from MP pneumonia and you can RWE communities

Demographic, clinical and laboratory data in both groups are shown in table 1. The mean age and age distribution were similar in both groups as shown in figure 3 (5.4 years vs 5.6 years, p=0.312). Both groups had male predominance, and there were more males in the RWE group. As expected, cases with wheezing at presentation, the proportion of patients with history or family history of allergic diseases, and history of wheezing were higher in the RWE group. Recurrent wheezing after discharge was observed in 38 of 180 patients with MP pneumonia and 141 of the 206 patients with RWE (p<0.001).

In MP pneumonia patients, 52 of the total 501 patients (10.4%) had wheezing at presentation, 72 (14.4%) had a history of allergic diseases, 15 (3%) had RWE according to our definition and 40 (8%) had a family history of allergic diseases. When we divided the MP pneumonia patients into two groups of patients with wheezing (n=52) and without wheezing (n=449), the patients with wheezing were younger (3.7 years vs 5.6 years, p<0.001) and had higher proportions of history allergic diseases and wheezing history and higher values of leucocyte count and eosinophil differential (table 2). Among the 52 MP pneumonia patients with wheezing at admission, 10 were patient with RWE, while 42 had no previous RWE history. Thus, in this study, 66% (10 of 15) of patients with RWE history presented with wheezing, while 8.6% of patients without RWE history (42 of 486) had wheezing at presentation. In a follow-up study of patients who visited two or more times after discharge, 13 (including 5 cases of RWE) of 21 MP pneumonia patients with initial wheezing and 25 (including 2 cases of RWE) of 159 MP pneumonia patients without wheezing had at least one wheezing episode after discharge (table 2). Although not all patients were followed-up, it was estimated that at least 31 of the total MP pneumonia patients (n=501, 6.2%) showed a recurrent wheezing after initial MP infection.

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