In silico Vaccine designing for Lyme disease

Abstract The vaccine designing project for Lyme disease involves various Bio-informatics tools and techniques for Insilico designing of a vaccine. Lyme disease is caused by the bacterium Borrelia Burgdorferi also called as Lyme Borreliosis or Lyme Arthritis. The bacterium uses ‘Ticks’ as vectors and infects Humans through tick bites. The symptoms can start from simple […]

MODERN DECELLULARIZATION SCAFFOLD FRAMING FROM PORCINE HEART VALVE

ABSTRACT Tissue engineering heart valve is a novel experimental concept to develop ideal heart valve substitutes. Conventional mechanical valve used for replacement require the anti-coagulation therapy which decreases quality of life. Now a days bioprosthetic heart valve replacement are either of animal origin such as porcine pulmonary or aortic valves and bovine pericardial valves or […]

NPHS2 Functional Variant (R229Q) in Primary Nephrotic Syndrome: A Study from South India

Abstract Nephrotic Syndrome (NS) comprises of Heavy Proteinuria, Hypo Albuminemia, Edema and Hyperlipidemia.  The worldwide prevalence of NS was reported to be 12-16 per 100,000 individuals; epidemiological evidence of a higher incidence of NS in children from South Asia. The present study focuses on the contribution of a common functional polymorphism R229Q (rs61747728) of NPHS2 […]

Insilico Vaccine Design against Zaire Ebolavirus

Abstract The best approach for the development of a vaccine against a specific infection or a microbial disease is Insilico vaccine designing that is not only accurate but also requires minimum time, labour and economy. This approach can also be used to analyze the target structures for possible binding/active sites, generate candidate molecules, check for […]